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Hodgkin lymphoma
High-YieldFree study guide for medical students and educators
~2 min readLast reviewed 2026-02-23
Also known as:Hodgkin's diseaseHodgkin diseaseHL
B‑cell lymphoma characterized by Reed–Sternberg (CD15+, CD30+) cells and contiguous nodal spread.
- Classically presents with B symptoms; highly curable with stage‑based therapy.
- Painless cervical/mediastinal nodes in a young adult
- Alcohol‑induced node pain (classic exam tidbit)
- Look for contiguous spread pattern; RS cells on histology
- Check for EBV association; define subtype (e.g., nodular sclerosis)
| Condition | Distinguishing Feature |
|---|---|
| non-hodgkin-lymphoma | non‑contiguous spread, more extranodal disease |
- ABVD‑based regimens; involved‑field radiation depending on stage
- RS cells = 'owl‑eye' nucleoli; CD15/CD30 positive
- Pruritus and Pel‑Ebstein fevers sometimes tested
- Mediastinal mass + B symptoms in young woman (nodular sclerosis)
⚡At a Glance
High-YieldSpecialtyHematology & Oncology
Key findingsPainless cervical/mediastinal nodes in a young adult; Alcohol‑induced node pain (classic exam tidbit)
TreatmentABVD‑based regimens; involved‑field radiation depending on stage
MnemonicRS cells = 'owl‑eye' nucleoli; CD15/CD30 positive